The science of health demands a new standard

With more health products than ever before, it has never been harder to know what information to trust, which products to choose, and what solutions you really need.

Our mission is to change this by creating the most trusted place to discover curated, quality-assessed health & wellness products from around the world.

Scientific rigor is our guiding principle. Before it goes in your body, it goes through us.

How our curation process works

2

Evaluate

Each product then undergoes a comprehensive vetting process over a six-week period. This extensive time window allows us to delve into the details of each standard. Brands are ultimately signed off on by our review committee of leading doctors, scientists, and pharmacologists.

We evaluate products across 11 factors, here are a few of our most important:

2.1 Evaluate

Scientific Rigor

Products should have substantial evidence from peer-reviewed studies. We scrutinize the science to ensure the product is safe and effective. We review how long the supporting science has been around, the strength of the scientific advisory board (SAB) behind it, and the quality of the publishing scientific journal.

This also includes assessing the years of data; the number of supported peer-reviewed articles with large sample sizes and proper randomization (double-blind, placebo-controlled); meta-analyses where present; strong support from scientific experts; and whether studies were done primarily on humans vs animals vs in vitro.

View our levels of evidence
Systematic Reviews & Meta-analysis Randomized Controlled Double Blind Studies Cohort Studies Case Series Case Reports Ideas, Editorials, Opinions Animal Research In Vitro (test tube) Research
2.2 Evaluate

Ingredient Quality

Supplements and wellness products are not regulated by the FDA, so we’ve created our own criteria for what’s considered safe versus not with a NO list to avoid supplements with toxic chemicals, microplastics, preservatives, flavors, colors and other provably harmful ingredients.

500+

Banned ingredients

View list

We do the same for personal care and clean home products and so far have banned 500+ harmful ingredients from parabens, phthalates and oxybenzones – so that you know anything on the Superpower marketplace is a product you can trust.

Finally, we look at independent quality testing for purity, strength, identity, and disintegration from the most reputable sources on the internet including:

View our list of sources

These sources are valuable for evaluating the safety and non-toxicity of products, providing consumers with reliable information to make informed choices.

Environmental Working Group (EWG)
EWG is known for providing tools and resources to make better choices regarding toxic-free, safe products in various categories, including household and consumer products.

The WellBe Non-Toxic Product Database
This database features over 2000 curated non-toxic products vetted by third-party unbiased organizations like Environmental Working Group, Think Dirty, MadeSafe, GreenGuard, ConsumerLab, NSF, and more.

Think Dirty App
This app allows users to check for chemicals in products by entering the product name or scanning the barcode. It provides a toxicity rating and suggests safe and cleaner alternatives.

MadeSafe
This organization provides certification for non-toxic products, ensuring they are free from harmful chemicals.

ConsumerLab
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Examine
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

NSF Supplement Vitamin Certification
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Clean Label Project
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Lab Door
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.
2.3 Evaluate

Manufacturing Standards & Sourcing

Manufacturing and sourcing standards are key to understanding product quality.

For supplements, we screen for designations such as CLIA, GMP, NSF, and FDA, which together help inform the quality of the manufacturing and sourcing process.

For food products, our screening extends to examining the quality of the ingredients and methods used in production, such as whether the food is grass-fed, processed vegetable oil free, and organic.

Beyond the products themselves, our holistic evaluation looks across the entire supply chain. We perform company background checks and ensure there are not concerns with products or their supply chains.

2.4 Evaluate

Price & Value

We have a deep commitment to balancing affordability with quality, and price with performance, ensuring that members receive excellent value in every product they order.

We measure product efficacy not just in numbers but also through the satisfaction of the broader customer universe, aiming for brands that have a substantial collection of genuine, positive customer reviews

2.5 Evaluate

Mission Alignment

The brand’s mission must supports or mirrors Superpower’s mission to bring preventative care to all and increase human lifespan and healthspan by preventing chronic disease through the pillars of environment, sleep, mental health, physical health, and nutrition.

3

Monitor

Once a product is accepted into the Superpower marketplace, it's not the end of our due diligence.

We reassess products every six months to ensure continued compliance with our brand standards and the latest research.

Ensuring lifelong quality through regular monitoring and re-evaluation.

As science advances, so will the quality of your lifelong health partnership with Superpower – with product recommendations always reflecting the latest in health innovation and research.

Ultimately, we aim to be so confident with all approved products that our medical team would personally use them themselves or recommend them to their loved ones.

The Members-Only Marketplace Promise

Superpower curates the top 1% of health items from around the world, and our research team conducts comprehensive evaluations to ensure top levels of quality, safety, and scientific robustness.

We ensure that our prices are better than anywhere else on the internet and provide them at a special, negotiated discount to save you money.

We don’t sell our own branded products, we don’t make extra margin on products and our clinical team is NEVER compensated on sales.

Our promise is to always be scientifically rigorous and 100% incentive aligned with you.

FREE Shipping for orders over $150

FREE Shipping for orders over $150

Superpower Marketplace
Superpower Marketplace
5-MTHF 5 mg - Superpower Marketplace
5-MTHF 5 mg - Superpower Marketplace
5-MTHF 5 mg - Superpower Marketplace
5-MTHF 5 mg - Superpower Marketplace
5-MTHF 5 mg - Superpower Marketplace
5-MTHF 5 mg - Superpower Marketplace
5-MTHF 5 mg - Superpower Marketplace
Thorne

5-MTHF 5 mg

$1999
About This Item
The active, tissue-ready form of folate, an essential B vitamin that supports heart, brain, blood health, and fertility.
Ingredients
Folate (L-5-MTHF), Hypromellose Capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide.
Why We Chose This
Most people are not getting enough folate in their diet. Further, approximately 60% of US adults have a genetic variation that affects their methylation cycle and folate utilization. [description] Thorne's formulation provides a bioactive form of folate (methylfolate) that is superior to many standard folic acid supplements in effectiveness and bioavailability, especially for individuals with genetic variations affecting folate metabolism.
5-MTHF 5 mg - Superpower Marketplace
5-MTHF 5 mg Default Title

About 5-MTHF 5 mg

Benefits
  • Supports healthy brain function and mood: An adequate amount of 5-MTHF is essential for the production of the neurotransmitters serotonin, melatonin, dopamine, and epinephrine.
  • Methyl-group donor: Acting with vitamin B12, 5-MTHF functions as a methyl-group donor, thereby facilitating healthy methylation and homocysteine levels.
  • Provides support during pregnancy: Folic acid is especially important before conception and during early pregnancy, because its biggest need is during the first trimester.
  • Supports heart, brain, and blood health: Has active folate to support nerve and cardiovascular health.

Suggested Use

Take 1 capsule one to two times per day or as recommended by your health professional. We recommend taking it with a meal.

Supporting Research

Why is 5-MTHF important?

Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.

Benefits
  • Supports healthy brain function and mood: An adequate amount of 5-MTHF is essential for the production of the neurotransmitters serotonin, melatonin, dopamine, and epinephrine.
  • Methyl-group donor: Acting with vitamin B12, 5-MTHF functions as a methyl-group donor, thereby facilitating healthy methylation and homocysteine levels.
  • Provides support during pregnancy: Folic acid is especially important before conception and during early pregnancy, because its biggest need is during the first trimester.
  • Supports heart, brain, and blood health: Has active folate to support nerve and cardiovascular health.

Suggested Use

Take 1 capsule one to two times per day or as recommended by your health professional. We recommend taking it with a meal.

Supporting Research

Why is 5-MTHF important?

Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.

Benefits
  • Supports healthy brain function and mood: An adequate amount of 5-MTHF is essential for the production of the neurotransmitters serotonin, melatonin, dopamine, and epinephrine.
  • Methyl-group donor: Acting with vitamin B12, 5-MTHF functions as a methyl-group donor, thereby facilitating healthy methylation and homocysteine levels.
  • Provides support during pregnancy: Folic acid is especially important before conception and during early pregnancy, because its biggest need is during the first trimester.
  • Supports heart, brain, and blood health: Has active folate to support nerve and cardiovascular health.

Suggested Use

Take 1 capsule one to two times per day or as recommended by your health professional. We recommend taking it with a meal.

Supporting Research

Why is 5-MTHF important?

Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.

Benefits
  • Supports healthy brain function and mood: An adequate amount of 5-MTHF is essential for the production of the neurotransmitters serotonin, melatonin, dopamine, and epinephrine.
  • Methyl-group donor: Acting with vitamin B12, 5-MTHF functions as a methyl-group donor, thereby facilitating healthy methylation and homocysteine levels.
  • Provides support during pregnancy: Folic acid is especially important before conception and during early pregnancy, because its biggest need is during the first trimester.
  • Supports heart, brain, and blood health: Has active folate to support nerve and cardiovascular health.

Suggested Use

Take 1 capsule one to two times per day or as recommended by your health professional. We recommend taking it with a meal.

Supporting Research

Why is 5-MTHF important?

Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.

Benefits
  • Supports healthy brain function and mood: An adequate amount of 5-MTHF is essential for the production of the neurotransmitters serotonin, melatonin, dopamine, and epinephrine.
  • Methyl-group donor: Acting with vitamin B12, 5-MTHF functions as a methyl-group donor, thereby facilitating healthy methylation and homocysteine levels.
  • Provides support during pregnancy: Folic acid is especially important before conception and during early pregnancy, because its biggest need is during the first trimester.
  • Supports heart, brain, and blood health: Has active folate to support nerve and cardiovascular health.

Suggested Use

Take 1 capsule one to two times per day or as recommended by your health professional. We recommend taking it with a meal.

Supporting Research

Why is 5-MTHF important?

Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.

For Superpower Members, text your private concierge at any time with any question

Our Curation Standards

The Superpower Research Team curates the top 1% of health items from around the world for top levels of ingredient quality, safety, and scientific efficacy.

Other Members Also Ordered

See all