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Evaluate

Each product then undergoes a comprehensive vetting process over a six-week period. This extensive time window allows us to delve into the details of each standard. Brands are ultimately signed off on by our review committee of leading doctors, scientists, and pharmacologists.

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2.1 Evaluate

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Finally, we look at independent quality testing for purity, strength, identity, and disintegration from the most reputable sources on the internet including:

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These sources are valuable for evaluating the safety and non-toxicity of products, providing consumers with reliable information to make informed choices.

Environmental Working Group (EWG)
EWG is known for providing tools and resources to make better choices regarding toxic-free, safe products in various categories, including household and consumer products.

The WellBe Non-Toxic Product Database
This database features over 2000 curated non-toxic products vetted by third-party unbiased organizations like Environmental Working Group, Think Dirty, MadeSafe, GreenGuard, ConsumerLab, NSF, and more.

Think Dirty App
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ConsumerLab
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Examine
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

NSF Supplement Vitamin Certification
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Clean Label Project
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Lab Door
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.
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For supplements, we screen for designations such as CLIA, GMP, NSF, and FDA, which together help inform the quality of the manufacturing and sourcing process.

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Beyond the products themselves, our holistic evaluation looks across the entire supply chain. We perform company background checks and ensure there are not concerns with products or their supply chains.

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We measure product efficacy not just in numbers but also through the satisfaction of the broader customer universe, aiming for brands that have a substantial collection of genuine, positive customer reviews

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The brand’s mission must supports or mirrors Superpower’s mission to bring preventative care to all and increase human lifespan and healthspan by preventing chronic disease through the pillars of environment, sleep, mental health, physical health, and nutrition.

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Monitor

Once a product is accepted into the Superpower marketplace, it's not the end of our due diligence.

We reassess products every six months to ensure continued compliance with our brand standards and the latest research.

Ensuring lifelong quality through regular monitoring and re-evaluation.

As science advances, so will the quality of your lifelong health partnership with Superpower – with product recommendations always reflecting the latest in health innovation and research.

Ultimately, we aim to be so confident with all approved products that our medical team would personally use them themselves or recommend them to their loved ones.

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Low Dose Naltrexone - Superpower Marketplace
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Low Dose Naltrexone

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A promising immunomodulatory agent for many immune-related diseases.

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Low Dose Naltrexone - Superpower Marketplace
Low Dose Naltrexone Default Title

The science of Low Dose Naltrexone

Active ingredients

The active ingredient in low dose naltrexone (LDN) is naltrexone hydrochloride, typically administered in very low doses ranging from 1.5 to 4.5 milligrams. In addition to the active ingredient, LDN formulations may contain inactive ingredients such as fillers, binders, and coating agents to facilitate proper dosage form and administration.

Mechanism

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

History

Low Dose Naltrexone (LDN) has a rich history of over 40 years of prescription use, primarily known for its exceptional safety record. Originally FDA-approved for treating opioid dependencies and obesity at higher doses, LDN gained prominence for its alternative use at lower dosages, with 4.5mg/day being the most common. Beyond its conventional applications, LDN has exhibited novel and paradoxical effects, garnering attention for potential therapeutic benefits across various conditions. Since 1985, LDN has been explored in the treatment of autoimmune diseases and viral infections, sparking ongoing research and discussions within the medical community.

How to get Low Dose Naltrexone

Get started

Frequently Asked Questions

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for low dose naltrexone (LDN) typically has a chronic condition such as autoimmune disease, chronic pain, or inflammation. They may also be seeking alternatives to traditional treatments or have had limited success with conventional therapies.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources

How do I use Low Dose Naltrexone?

Low Dose Naltrexone (LDN) is typically administered orally, and the recommended dosage often falls within the range of 1 to 5 mg. It is crucial to follow the prescribed dosage and administration guidelines provided by healthcare professionals. LDN is commonly taken at night before bedtime to minimize potential side effects, and it is advisable to avoid consuming opioid-containing medications during the LDN regimen to prevent interference with its effects.

How does Low Dose Naltrexone effect my body?

Naltrexone is nearly entirely absorbed (96%) upon oral administration, but its oral bioavailability varies from 5% to 40% due to first-pass metabolism in the liver. The half-life of naltrexone is about 4 hours. The liver metabolizes over 98% of naltrexone, generating the primary metabolite 6-β-naltrexol, which also acts as an antagonist on opioid receptors and has a half-life of 13 hours. Renal elimination, primarily through glomerular filtration, is responsible for a small portion of unchanged naltrexone, while 6-β-naltrexol is excreted.

Special Considerations
  • Reproductive considerations: This product should not be used in women who are attempting to conceive or at high risk for pregnancy.
  • Pregnancy considerations: This product should not be used during pregnancy. Naltrexone and the 6-beta-naltrexol metabolite cross the placenta and there are limited studies to show the long-term impact of exposure to the fetus.
  • Breastfeeding considerations: This product should not be used during breastfeeding. Naltrexone and the 6-beta-naltrexol metabolite are present in breast milk and there are limited studies to show the long-term impact of exposure to a developing infant.

How do I safely store Low Dose Naltrexone?

Store Low Dose Naltrexone (LDN) in a cool, dry place, away from direct sunlight and moisture. Keep the medication in its original packaging and ensure it is securely sealed to maintain its stability and efficacy. It is essential to follow specific storage instructions provided by healthcare professionals or on the medication label to preserve the integrity of LDN.

What conditions is low dose naltrexone (LDN) commonly used for?

LDN has shown promise in managing various conditions such as autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and Crohn's disease, as well as chronic pain conditions like fibromyalgia and neuropathic pain. Research also suggests potential benefits for mood disorders, neurodegenerative diseases, and immune system dysregulation.

What is the mechanism of action behind low dose naltrexone (LDN)?

LDN works by temporarily blocking opioid receptors in the brain, which leads to a rebound increase in endorphin production. This increase in endorphins is believed to modulate immune function, reduce inflammation, and potentially alleviate symptoms associated with various conditions.

Are there any significant side effects or risks associated with low dose naltrexone (LDN)?

Naltrexone administration can lead to a variety of side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

For Superpower Members, text your private concierge at any time with any question

Important safety information

Potential Side Effects

While Low Dose Naltrexone (LDN) is generally well-tolerated, some individuals can experience side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

Contraindications

Any of the following are contraindications to taking the medication:

  • People with hypersensitivity to any component of the medication
  • Current physiological opioid dependence or current use of opioid analgesics (including partial opioid agonists)
  • Acute opioid withdrawal
  • People with alcohol use disorder
  • Moderate-Severe Liver Disease
  • Moderate-Severe Kidney Disease
  • History of Depression
  • History of Suicide Ideation or Attempt
  • Pregnant women, women attempting to conceive, and women at high risk of pregnancy
  • Women who are breast-feeding

Drug Interactions

Interacting drugs include, but not limited to:

  • Bremelanotide: May decrease the serum concentration of Naltrexone. *Risk X: Avoid combination*
  • Lofexidine: May decrease the serum concentration of Naltrexone. *Risk C: Monitor therapy*
  • Methylnaltrexone: May enhance the adverse/toxic effect of Opioid Antagonists. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Naldemedine: Opioid Antagonists may enhance the adverse/toxic effect of Naldemedine. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Naloxegol: Opioid Antagonists may enhance the adverse/toxic effect of Naloxegol. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Opioid Agonists: Naltrexone may diminish the therapeutic effect of Opioid Agonists. Management: Seek therapeutic alternatives to opioids. See full drug interaction monograph for detailed recommendations. *Risk X: Avoid combination*
  • Sibutramine: May enhance the adverse/toxic effect of Centrally Acting Weight Loss Agents. *Risk X: Avoid combination*

Potential Side Effects

While Low Dose Naltrexone (LDN) is generally well-tolerated, some individuals can experience side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

Contraindications

Any of the following are contraindications to taking the medication:

  • People with hypersensitivity to any component of the medication
  • Current physiological opioid dependence or current use of opioid analgesics (including partial opioid agonists)
  • Acute opioid withdrawal
  • People with alcohol use disorder
  • Moderate-Severe Liver Disease
  • Moderate-Severe Kidney Disease
  • History of Depression
  • History of Suicide Ideation or Attempt
  • Pregnant women, women attempting to conceive, and women at high risk of pregnancy
  • Women who are breast-feeding

Drug Interactions

Interacting drugs include, but not limited to:

  • Bremelanotide: May decrease the serum concentration of Naltrexone. *Risk X: Avoid combination*
  • Lofexidine: May decrease the serum concentration of Naltrexone. *Risk C: Monitor therapy*
  • Methylnaltrexone: May enhance the adverse/toxic effect of Opioid Antagonists. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Naldemedine: Opioid Antagonists may enhance the adverse/toxic effect of Naldemedine. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Naloxegol: Opioid Antagonists may enhance the adverse/toxic effect of Naloxegol. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Opioid Agonists: Naltrexone may diminish the therapeutic effect of Opioid Agonists. Management: Seek therapeutic alternatives to opioids. See full drug interaction monograph for detailed recommendations. *Risk X: Avoid combination*
  • Sibutramine: May enhance the adverse/toxic effect of Centrally Acting Weight Loss Agents. *Risk X: Avoid combination*

Potential Side Effects

While Low Dose Naltrexone (LDN) is generally well-tolerated, some individuals can experience side effects across multiple body systems. Gastrointestinal effects are common, with nausea occurring in 33% of patients, and other symptoms like abdominal pain, decreased appetite, diarrhea, and vomiting also reported. The nervous system can be affected, with notable side effects including anxiety, asthenia, headaches, insomnia, and dizziness. Liver enzyme levels may increase, indicating potential hepatic side effects, and neuromuscular & skeletal complaints such as arthralgia, arthritis, and increased creatine phosphokinase levels are observed. Less common and postmarketing side effects span a wide range, including dermatologic, respiratory, cardiovascular, and hypersensitivity reactions, highlighting the broad impact naltrexone can have on patients.

Contraindications

Any of the following are contraindications to taking the medication:

  • People with hypersensitivity to any component of the medication
  • Current physiological opioid dependence or current use of opioid analgesics (including partial opioid agonists)
  • Acute opioid withdrawal
  • People with alcohol use disorder
  • Moderate-Severe Liver Disease
  • Moderate-Severe Kidney Disease
  • History of Depression
  • History of Suicide Ideation or Attempt
  • Pregnant women, women attempting to conceive, and women at high risk of pregnancy
  • Women who are breast-feeding

Drug Interactions

Interacting drugs include, but not limited to:

  • Bremelanotide: May decrease the serum concentration of Naltrexone. *Risk X: Avoid combination*
  • Lofexidine: May decrease the serum concentration of Naltrexone. *Risk C: Monitor therapy*
  • Methylnaltrexone: May enhance the adverse/toxic effect of Opioid Antagonists. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Naldemedine: Opioid Antagonists may enhance the adverse/toxic effect of Naldemedine. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Naloxegol: Opioid Antagonists may enhance the adverse/toxic effect of Naloxegol. Specifically, the risk for opioid withdrawal may be increased. *Risk X: Avoid combination*
  • Opioid Agonists: Naltrexone may diminish the therapeutic effect of Opioid Agonists. Management: Seek therapeutic alternatives to opioids. See full drug interaction monograph for detailed recommendations. *Risk X: Avoid combination*
  • Sibutramine: May enhance the adverse/toxic effect of Centrally Acting Weight Loss Agents. *Risk X: Avoid combination*

For Superpower Members, text your private concierge at any time with any question

Our Curation Standards

At Superpower, we believe in scientific rigor and transparency. We have a dedicated medical and research team that follows a multi-faceted curation and evaluation process to select only the most trusted and efficacious products and protocols for our members.

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