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Our mission is to change this by creating the most trusted place to discover curated, quality-assessed health & wellness products from around the world.

Scientific rigor is our guiding principle. Before it goes in your body, it goes through us.

How our curation process works

2

Evaluate

Each product then undergoes a comprehensive vetting process over a six-week period. This extensive time window allows us to delve into the details of each standard. Brands are ultimately signed off on by our review committee of leading doctors, scientists, and pharmacologists.

We evaluate products across 11 factors, here are a few of our most important:

2.1 Evaluate

Scientific Rigor

Products should have substantial evidence from peer-reviewed studies. We scrutinize the science to ensure the product is safe and effective. We review how long the supporting science has been around, the strength of the scientific advisory board (SAB) behind it, and the quality of the publishing scientific journal.

This also includes assessing the years of data; the number of supported peer-reviewed articles with large sample sizes and proper randomization (double-blind, placebo-controlled); meta-analyses where present; strong support from scientific experts; and whether studies were done primarily on humans vs animals vs in vitro.

View our levels of evidence
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Ingredient Quality

Supplements and wellness products are not regulated by the FDA, so we’ve created our own criteria for what’s considered safe versus not with a NO list to avoid supplements with toxic chemicals, microplastics, preservatives, flavors, colors and other provably harmful ingredients.

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We do the same for personal care and clean home products and so far have banned 500+ harmful ingredients from parabens, phthalates and oxybenzones – so that you know anything on the Superpower marketplace is a product you can trust.

Finally, we look at independent quality testing for purity, strength, identity, and disintegration from the most reputable sources on the internet including:

View our list of sources

These sources are valuable for evaluating the safety and non-toxicity of products, providing consumers with reliable information to make informed choices.

Environmental Working Group (EWG)
EWG is known for providing tools and resources to make better choices regarding toxic-free, safe products in various categories, including household and consumer products.

The WellBe Non-Toxic Product Database
This database features over 2000 curated non-toxic products vetted by third-party unbiased organizations like Environmental Working Group, Think Dirty, MadeSafe, GreenGuard, ConsumerLab, NSF, and more.

Think Dirty App
This app allows users to check for chemicals in products by entering the product name or scanning the barcode. It provides a toxicity rating and suggests safe and cleaner alternatives.

MadeSafe
This organization provides certification for non-toxic products, ensuring they are free from harmful chemicals.

ConsumerLab
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Examine
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

NSF Supplement Vitamin Certification
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Clean Label Project
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Lab Door
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.
2.3 Evaluate

Manufacturing Standards & Sourcing

Manufacturing and sourcing standards are key to understanding product quality.

For supplements, we screen for designations such as CLIA, GMP, NSF, and FDA, which together help inform the quality of the manufacturing and sourcing process.

For food products, our screening extends to examining the quality of the ingredients and methods used in production, such as whether the food is grass-fed, processed vegetable oil free, and organic.

Beyond the products themselves, our holistic evaluation looks across the entire supply chain. We perform company background checks and ensure there are not concerns with products or their supply chains.

2.4 Evaluate

Price & Value

We have a deep commitment to balancing affordability with quality, and price with performance, ensuring that members receive excellent value in every product they order.

We measure product efficacy not just in numbers but also through the satisfaction of the broader customer universe, aiming for brands that have a substantial collection of genuine, positive customer reviews

2.5 Evaluate

Mission Alignment

The brand’s mission must supports or mirrors Superpower’s mission to bring preventative care to all and increase human lifespan and healthspan by preventing chronic disease through the pillars of environment, sleep, mental health, physical health, and nutrition.

3

Monitor

Once a product is accepted into the Superpower marketplace, it's not the end of our due diligence.

We reassess products every six months to ensure continued compliance with our brand standards and the latest research.

Ensuring lifelong quality through regular monitoring and re-evaluation.

As science advances, so will the quality of your lifelong health partnership with Superpower – with product recommendations always reflecting the latest in health innovation and research.

Ultimately, we aim to be so confident with all approved products that our medical team would personally use them themselves or recommend them to their loved ones.

The Members-Only Marketplace Promise

Superpower curates the top 1% of health items from around the world, and our research team conducts comprehensive evaluations to ensure top levels of quality, safety, and scientific robustness.

We ensure that our prices are better than anywhere else on the internet and provide them at a special, negotiated discount to save you money.

We don’t sell our own branded products, we don’t make extra margin on products and our clinical team is NEVER compensated on sales.

Our promise is to always be scientifically rigorous and 100% incentive aligned with you.

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Enclomiphene

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Enclomiphene Default Title

The science of Enclomiphene

Active ingredients

Enclomiphene citrate, the active pharmaceutical ingredient, is the primary component of enclomiphene. It's formulated with inactive ingredients like microcrystalline cellulose, lactose monohydrate, magnesium stearate, and colloidal silicon dioxide to form tablets for oral administration.

Mechanism

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

History

Enclomiphene, is a non-FDA-approved medication that has garnered attention for its off-label application in the treatment of hypogonadism in males. It is an isomer of Clomiphene Citrate (brand name: Clomid), an FDA approved medication for the indication ovulatory dysfunction in women desiring pregnancy. Unlike its conventional use, enclomiphene's potential in managing low testosterone levels is a newer exploration. While the FDA has not specifically approved enclomiphene for hypogonadism, healthcare professionals consider its use for this purpose.



A growing body of evidence suggests that enclomiphene may be a rapid and more effective treatment than Clomiphene citrate for treating secondary hypogonadism in men. Male secondary hypogonadism is a clinical syndrome caused by androgen deficiency attributed to the hypothalamic-pituitary-gonadal (HPG) axis. Initial studies indicate that Enclomiphene citrate possesses distinct advantages over Clomid (clomiphene citrate) and aromatase inhibitors for managing secondary hypogonadism. Firstly, enclomiphene citrate is the trans-isomer of clomiphene citrate and exhibits higher potency in stimulating the hypothalamic-pituitary-gonadal axis. This improved specificity enables enclomiphene citrate to effectively increase testosterone levels while minimizing estrogen-related side effects. Moreover, unlike aromatase inhibitors, enclomiphene citrate does not inhibit the aromatase enzyme responsible for converting testosterone into estrogen. This property allows enclomiphene citrate to maintain appropriate estrogen levels, contributing to better overall hormonal balance.

How to get Enclomiphene

Get started

Frequently Asked Questions

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

Eligibility for Enclomiphene Treatment with Superpower entails a careful assessment via asynchronous review of an intake form. Candidates suitable for this treatment should exhibit symptoms indicative of testosterone deficiency.

What states is this available in?

California, New York, Florida, Texas, Colorado and Nevada

Supporting science and sources
  • National Library of Medicine - Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism
  • BJU International - Testosterone restoration using enclomiphene citrate in men with secondary hypogonadism: a pharmacodynamic and pharmacokinetic study

How do I use Enclomiphene?

Enclomiphene is administered orally in tablet form. The recommended dosage and duration of treatment vary based on the specific medical condition being addressed and goals of treatment. A Superpower physician will prescribe in individual protocol including dosing plans, follow-up testing, and surveys to ensure proper monitoring and adjustment of the treatment plan if necessary.

How does Enclomiphene effect my body?

Enclomiphene's mechanism of action primarily involves its role as a selective estrogen receptor modulator (SERM). It exerts its therapeutic effects by influencing the delicate balance of hormones within the hypothalamic-pituitary-gonadal (HPG) axis, which plays a central role in regulating reproductive and sexual function in both men and women. In men, enclomiphene's primary role is to block estrogen receptors in the hypothalamus, leading to an increase in the secretion of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the release of luteinizing hormone (LH) from the pituitary gland, prompting the testes to produce more testosterone.

Special Considerations

When taken responsibly under the guidance of a healthcare professional, enclomiphene has been shown to be a generally well-tolerated drug in men with minimal to no persistent physical, emotional, or psychological symptoms after administration.



Certain serious side effects linked to enclomiphene warrant immediate medical attention. These may manifest as allergic reactions characterized by difficulty in breathing, facial, lip, tongue, or throat swelling, and the appearance of hives. If any of these symptoms occur, prompt medical assistance is imperative.



Other severe side effects linked to enclomiphene may encompass alterations in vision, including blurred vision or perception of light flashes. Patients may also experience chest pain, breathing difficulties, or leg swelling, which could be indicative of a blood clot. In the presence of any of these symptoms, it is crucial for the member to understand they should promptly notify their healthcare provider.



It is also noteworthy that enclomiphene may heighten the risk of certain types of cancer, including breast cancer, endometrial cancer, and ovarian cancer. Enclomiphene exerts estrogenic effects making it unsuitable for members with a history of estrogen-sensitive cancers. Patients with a history of these malignancies or a family history thereof should engage in a discussion with their healthcare provider to assess their individual risks before considering enclomiphene treatment.

How do I safely store Enclomiphene?

Enclomiphene should be stored in a cool, dry place at room temperature, away from direct sunlight and moisture. It is crucial to keep the medication out of reach of children and pets. Patients should adhere to any specific storage instructions provided with the medication packaging to maintain its stability and effectiveness throughout the prescribed duration.

Does enclomiphene cause infertility?

No, one of the key advantages of taking enclomiphene instead of testosterone replacement therapy is that enclomiphene maintains a normal brain, pituitary, and testes axis.



It increases testosterone production while maintaining normal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.



In clinical studies, men taking enclomiphene maintained or increased their sperm motility and total sperm count.

Is enclomiphene a form of TRT?

No, enclomiphene is an alternative to TRT.



Like testosterone replacement therapy (TRT), enclomiphene is used to increase testosterone levels in men with low testosterone and hypogonadism.Hypogonadism is a condition in which the testes do not produce enough testosterone.

What is Clomid?

Clomid is a mixture of two isomers: zuclomiphene and enclomiphene. Zuclomiphene is a weak estrogen agonist with a long half-life, and enclomiphene is an estrogen antagonist with a much shorter half-life.



When taking Clomid, you receive the benefits of enclomiphene but must deal with the side effects of zuclomiphene.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

For Superpower Members, text your private concierge at any time with any question

Important safety information

Potential Side Effects

Common side effects include (% = percentage of patients that experienced side effects during the clinical trial)

  • Headache (3.3%)
  • Nausea (2.1%)
  • Diarrhea (1.9%)
  • Common cold (1.7%)
  • Hot flush (1.7%)
  • Joint pain (1.2%)
  • Dizziness (1%)
  • Muscle spasms (0.9%)
  • Fatigue (0.6%)
  • Increased appetite (0.6%)
  • Aggression (0.5%)
  • Irritability (0.5%)
  • Acne (0.5%)
  • Increased libido
  • Mood swings if testosterone levels get too high

Contraindications

Enclomiphene is potentially contraindicated in members who meet any of the following criteria and further assessment should be completed by the Superpower clinician and documented prior to the prescription of Enclomiphene:

  • Female sex (assigned at birth)
  • History of breast, endometrial (uterine), ovarian, or prostate cancer.
  • History or pre-existing risk of blood clots
  • History of heart disease
  • Presence of current pituitary adenoma
  • History of liver disease.
  • Uncontrolled adrenal or thyroid dysfunction.
  • Known allergy to enclomiphene or clomiphene.
  • History of mania, bipolar disorder, or current manic symptoms (d/t risk of mood swings)

Pregnancy Risks:

Enclomiphene is not recommended for use during pregnancy due to a lack of data from controlled studies in humans. The FDA has not assigned a pregnancy risk category to the substance.

Drug Interactions

Enclomiphene's interactions with other medications should be carefully assessed to ensure optimal safety and efficacy. Individuals using drugs metabolized by the liver, especially those affecting the cytochrome P450 system, may experience altered metabolism when concurrently using enclomiphene. Additionally, caution is advised when combining enclomiphene with other hormonal therapies, as potential synergistic or antagonistic effects could influence overall therapeutic outcomes. It is crucial for healthcare professionals to thoroughly review a patient's medication profile and consider potential interactions before prescribing enclomiphene.

Potential Side Effects

Common side effects include (% = percentage of patients that experienced side effects during the clinical trial)

  • Headache (3.3%)
  • Nausea (2.1%)
  • Diarrhea (1.9%)
  • Common cold (1.7%)
  • Hot flush (1.7%)
  • Joint pain (1.2%)
  • Dizziness (1%)
  • Muscle spasms (0.9%)
  • Fatigue (0.6%)
  • Increased appetite (0.6%)
  • Aggression (0.5%)
  • Irritability (0.5%)
  • Acne (0.5%)
  • Increased libido
  • Mood swings if testosterone levels get too high

Contraindications

Enclomiphene is potentially contraindicated in members who meet any of the following criteria and further assessment should be completed by the Superpower clinician and documented prior to the prescription of Enclomiphene:

  • Female sex (assigned at birth)
  • History of breast, endometrial (uterine), ovarian, or prostate cancer.
  • History or pre-existing risk of blood clots
  • History of heart disease
  • Presence of current pituitary adenoma
  • History of liver disease.
  • Uncontrolled adrenal or thyroid dysfunction.
  • Known allergy to enclomiphene or clomiphene.
  • History of mania, bipolar disorder, or current manic symptoms (d/t risk of mood swings)

Pregnancy Risks:

Enclomiphene is not recommended for use during pregnancy due to a lack of data from controlled studies in humans. The FDA has not assigned a pregnancy risk category to the substance.

Drug Interactions

Enclomiphene's interactions with other medications should be carefully assessed to ensure optimal safety and efficacy. Individuals using drugs metabolized by the liver, especially those affecting the cytochrome P450 system, may experience altered metabolism when concurrently using enclomiphene. Additionally, caution is advised when combining enclomiphene with other hormonal therapies, as potential synergistic or antagonistic effects could influence overall therapeutic outcomes. It is crucial for healthcare professionals to thoroughly review a patient's medication profile and consider potential interactions before prescribing enclomiphene.

Potential Side Effects

Common side effects include (% = percentage of patients that experienced side effects during the clinical trial)

  • Headache (3.3%)
  • Nausea (2.1%)
  • Diarrhea (1.9%)
  • Common cold (1.7%)
  • Hot flush (1.7%)
  • Joint pain (1.2%)
  • Dizziness (1%)
  • Muscle spasms (0.9%)
  • Fatigue (0.6%)
  • Increased appetite (0.6%)
  • Aggression (0.5%)
  • Irritability (0.5%)
  • Acne (0.5%)
  • Increased libido
  • Mood swings if testosterone levels get too high

Contraindications

Enclomiphene is potentially contraindicated in members who meet any of the following criteria and further assessment should be completed by the Superpower clinician and documented prior to the prescription of Enclomiphene:

  • Female sex (assigned at birth)
  • History of breast, endometrial (uterine), ovarian, or prostate cancer.
  • History or pre-existing risk of blood clots
  • History of heart disease
  • Presence of current pituitary adenoma
  • History of liver disease.
  • Uncontrolled adrenal or thyroid dysfunction.
  • Known allergy to enclomiphene or clomiphene.
  • History of mania, bipolar disorder, or current manic symptoms (d/t risk of mood swings)

Pregnancy Risks:

Enclomiphene is not recommended for use during pregnancy due to a lack of data from controlled studies in humans. The FDA has not assigned a pregnancy risk category to the substance.

Drug Interactions

Enclomiphene's interactions with other medications should be carefully assessed to ensure optimal safety and efficacy. Individuals using drugs metabolized by the liver, especially those affecting the cytochrome P450 system, may experience altered metabolism when concurrently using enclomiphene. Additionally, caution is advised when combining enclomiphene with other hormonal therapies, as potential synergistic or antagonistic effects could influence overall therapeutic outcomes. It is crucial for healthcare professionals to thoroughly review a patient's medication profile and consider potential interactions before prescribing enclomiphene.

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At Superpower, we believe in scientific rigor and transparency. We have a dedicated medical and research team that follows a multi-faceted curation and evaluation process to select only the most trusted and efficacious products and protocols for our members.

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