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With more health products than ever before, it has never been harder to know what information to trust, which products to choose, and what solutions you really need.

Our mission is to change this by creating the most trusted place to discover curated, quality-assessed health & wellness products from around the world.

Scientific rigor is our guiding principle. Before it goes in your body, it goes through us.

How our curation process works

2

Evaluate

Each product then undergoes a comprehensive vetting process over a six-week period. This extensive time window allows us to delve into the details of each standard. Brands are ultimately signed off on by our review committee of leading doctors, scientists, and pharmacologists.

We evaluate products across 11 factors, here are a few of our most important:

2.1 Evaluate

Scientific Rigor

Products should have substantial evidence from peer-reviewed studies. We scrutinize the science to ensure the product is safe and effective. We review how long the supporting science has been around, the strength of the scientific advisory board (SAB) behind it, and the quality of the publishing scientific journal.

This also includes assessing the years of data; the number of supported peer-reviewed articles with large sample sizes and proper randomization (double-blind, placebo-controlled); meta-analyses where present; strong support from scientific experts; and whether studies were done primarily on humans vs animals vs in vitro.

View our levels of evidence
Systematic Reviews & Meta-analysis Randomized Controlled Double Blind Studies Cohort Studies Case Series Case Reports Ideas, Editorials, Opinions Animal Research In Vitro (test tube) Research
2.2 Evaluate

Ingredient Quality

Supplements and wellness products are not regulated by the FDA, so we’ve created our own criteria for what’s considered safe versus not with a NO list to avoid supplements with toxic chemicals, microplastics, preservatives, flavors, colors and other provably harmful ingredients.

500+

Banned ingredients

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We do the same for personal care and clean home products and so far have banned 500+ harmful ingredients from parabens, phthalates and oxybenzones – so that you know anything on the Superpower marketplace is a product you can trust.

Finally, we look at independent quality testing for purity, strength, identity, and disintegration from the most reputable sources on the internet including:

View our list of sources

These sources are valuable for evaluating the safety and non-toxicity of products, providing consumers with reliable information to make informed choices.

Environmental Working Group (EWG)
EWG is known for providing tools and resources to make better choices regarding toxic-free, safe products in various categories, including household and consumer products.

The WellBe Non-Toxic Product Database
This database features over 2000 curated non-toxic products vetted by third-party unbiased organizations like Environmental Working Group, Think Dirty, MadeSafe, GreenGuard, ConsumerLab, NSF, and more.

Think Dirty App
This app allows users to check for chemicals in products by entering the product name or scanning the barcode. It provides a toxicity rating and suggests safe and cleaner alternatives.

MadeSafe
This organization provides certification for non-toxic products, ensuring they are free from harmful chemicals.

ConsumerLab
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Examine
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

NSF Supplement Vitamin Certification
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Clean Label Project
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.

Lab Door
ConsumerLab is known for its comprehensive set of test results, including dosage, phytonutrient levels, and contaminant levels in various products.
2.3 Evaluate

Manufacturing Standards & Sourcing

Manufacturing and sourcing standards are key to understanding product quality.

For supplements, we screen for designations such as CLIA, GMP, NSF, and FDA, which together help inform the quality of the manufacturing and sourcing process.

For food products, our screening extends to examining the quality of the ingredients and methods used in production, such as whether the food is grass-fed, processed vegetable oil free, and organic.

Beyond the products themselves, our holistic evaluation looks across the entire supply chain. We perform company background checks and ensure there are not concerns with products or their supply chains.

2.4 Evaluate

Price & Value

We have a deep commitment to balancing affordability with quality, and price with performance, ensuring that members receive excellent value in every product they order.

We measure product efficacy not just in numbers but also through the satisfaction of the broader customer universe, aiming for brands that have a substantial collection of genuine, positive customer reviews

2.5 Evaluate

Mission Alignment

The brand’s mission must supports or mirrors Superpower’s mission to bring preventative care to all and increase human lifespan and healthspan by preventing chronic disease through the pillars of environment, sleep, mental health, physical health, and nutrition.

3

Monitor

Once a product is accepted into the Superpower marketplace, it's not the end of our due diligence.

We reassess products every six months to ensure continued compliance with our brand standards and the latest research.

Ensuring lifelong quality through regular monitoring and re-evaluation.

As science advances, so will the quality of your lifelong health partnership with Superpower – with product recommendations always reflecting the latest in health innovation and research.

Ultimately, we aim to be so confident with all approved products that our medical team would personally use them themselves or recommend them to their loved ones.

The Members-Only Marketplace Promise

Superpower curates the top 1% of health items from around the world, and our research team conducts comprehensive evaluations to ensure top levels of quality, safety, and scientific robustness.

We ensure that our prices are better than anywhere else on the internet and provide them at a special, negotiated discount to save you money.

We don’t sell our own branded products, we don’t make extra margin on products and our clinical team is NEVER compensated on sales.

Our promise is to always be scientifically rigorous and 100% incentive aligned with you.

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Metformin
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Metformin

Others are already seeing the results – why wait?

Improve insulin sensitivity and support metabolic health with Metformin.

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Metformin
Metformin Default Title

The science of Metformin

Active ingredients

The active ingredient in metformin is metformin hydrochloride. In addition to the active ingredient, metformin tablets may also contain inactive ingredients such as microcrystalline cellulose, magnesium stearate, hypromellose, and polyethylene glycol. These inactive ingredients serve various purposes, including as binders, lubricants, and fillers to form the tablet and aid in its dissolution.

Mechanism

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

History

Metformin, a cornerstone in diabetes management, traces its history back to the 1920s when the plant-derived compound Galega officinalis was noted for its glucose-lowering properties. The active ingredient, later identified as metformin, gained attention for its glucose-regulating effects. Fast forward to the late 1950s, and Metformin was introduced as an anti-diabetic medication, achieving FDA approval in 1994 for type 2 diabetes treatment. Its long-standing history and continuous evolution underscore its significance in the field of metabolic health.

How to get Metformin

Get started

Frequently Asked Questions

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

Am I a good candidate?

A good candidate for metformin typically has type 2 diabetes or prediabetes. Metformin is often recommended as a first-line medication due to its effectiveness in lowering blood sugar levels, particularly in individuals who are overweight or obese, as it can also help with weight management. Additionally, those with polycystic ovary syndrome (PCOS) may benefit from metformin due to its ability to regulate menstrual cycles and improve fertility.

What states is this available in?

CA, FL, NY, TX, CO, NV, NJ

Supporting science and sources

How do I use Metformin?

Metformin is typically taken orally with meals to reduce gastrointestinal side effects. The prescribed dosage varies depending on individual health conditions, and healthcare providers may recommend starting with a lower dose and gradually increasing it to achieve optimal therapeutic effects. Regular monitoring of blood glucose levels and adherence to healthcare provider instructions are essential for maximizing the benefits of Metformin therapy.

How does Metformin effect my body?

Metformin exhibits robust pharmacokinetics, with excellent oral absorption and bioavailability upon administration. After ingestion, it is efficiently absorbed through the gastrointestinal tract, reaching peak plasma concentrations within a few hours. The body primarily excretes Metformin unchanged through the kidneys, underscoring its renal elimination. Due to its relatively short half-life, regular dosing is often recommended to maintain therapeutic levels and harness its metabolic benefits effectively.

Special Considerations

Before initiating Metformin, healthcare providers should assess renal function and exercise caution in patients with known risk factors for lactic acidosis. Monitoring renal function regularly, especially in elderly individuals, helps mitigate potential risks. Individuals experiencing symptoms like rapid breathing, muscle pain, or stomach discomfort should seek prompt medical attention.

How do I safely store Metformin?

Metformin should be stored at room temperature, away from moisture, heat, and direct sunlight. It is crucial to keep the medication in its original packaging and ensure that the container is tightly closed to prevent moisture absorption. Like any medication, Metformin should be kept out of reach of children and pets.

How does Metformin affect Vitamin B12 levels?

Metformin can cause a reduction in Vitamin B12 levels, perhaps by interfering with its absorption, or by some other mechanism. For this reason, patients on Metformin should either monitor their B12 levels or take extra B12 out of precaution. However, some studies suggest that there is no significant connection between B12 levels and Metformin.



Regardless of whether or not you take Metformin, it is important to maintain proper levels of Vitamin B12. For adults under age 65, the easiest way to get B12 is to take at least one 2,000mcg supplement each week, or a daily dose of 50mcg.



As we age, our ability to absorb Vitamin B12 may decline. For those over 65 who eat plant-based diets, the supplementation should probably be increased up to 1,000mcg of B12 each day.

How does metformin work differently in individuals with varying degrees of insulin resistance?

Metformin primarily works by decreasing glucose production in the liver and improving insulin sensitivity in peripheral tissues. In individuals with high insulin resistance, metformin's ability to enhance insulin sensitivity becomes particularly crucial, as it helps tissues respond more effectively to insulin, leading to better glucose uptake and utilization.

Are there any emerging research findings suggesting potential benefits or risks of long-term metformin use beyond glycemic control, such as its impact on cardiovascular health or cancer prevention?

Metformin has shown promise in potentially reducing the risk of cardiovascular events and mortality among individuals with diabetes. Moreover, there are suggestions of its role in cancer prevention and treatment due to its impact on cellular metabolism and inflammation.

What does off-label usage mean?

Off-label usage refers to the practice of prescribing or using a medication, medical device, or treatment for a purpose that is not approved by regulatory authorities, such as the FDA (Food and Drug Administration) in the United States. This means that the medication is being used in a manner or for a condition that is not specifically listed on its label or approved product information. Off-label usage may occur when healthcare professionals believe that the treatment may be beneficial for a particular condition, based on clinical judgment, research, or anecdotal evidence, even if it has not been formally approved for that specific use.

For Superpower Members, text your private concierge at any time with any question

Important safety information

Potential Side Effects

Common side effects of Metformin include gastrointestinal symptoms such as nausea, diarrhea, and abdominal discomfort, especially when initiating treatment. These effects are often transient and can be mitigated by taking Metformin with meals or as directed by a healthcare professional. Persistent or severe side effects should be promptly reported to a healthcare provider for further evaluation and potential dosage adjustments.

Contraindications
  • Renal Impairment: Avoid Metformin in cases of severe renal impairment or dysfunction, as it relies on renal elimination for excretion. Regular monitoring of renal function is essential to ensure safe use.
  • Hepatic Insufficiency: Exercise caution in patients with hepatic insufficiency, and closely monitor liver function when using Metformin. Consultation with healthcare providers is advised to assess safety.
  • Heart Failure: Individuals with heart failure should use Metformin cautiously, as its use may exacerbate this condition. Regular cardiac assessments and medical supervision are recommended for those with heart failure considering Metformin.
  • Lactic Acidosis Predisposition: Metformin should be avoided in conditions that may predispose individuals to lactic acidosis, such as acute or chronic metabolic acidosis. Healthcare providers should carefully evaluate the risk factors before prescribing Metformin.

Drug Interactions

Metformin may interact with medications that affect renal function or involve the use of iodinated contrast agents, potentially increasing the risk of lactic acidosis. Certain drugs, like cimetidine, can alter Metformin absorption, emphasizing the importance of close monitoring and dosage adjustments when co-administered. Healthcare professionals should consider potential interactions and adjust treatment plans accordingly to ensure the safe and effective use of Metformin.

Potential Side Effects

Common side effects of Metformin include gastrointestinal symptoms such as nausea, diarrhea, and abdominal discomfort, especially when initiating treatment. These effects are often transient and can be mitigated by taking Metformin with meals or as directed by a healthcare professional. Persistent or severe side effects should be promptly reported to a healthcare provider for further evaluation and potential dosage adjustments.

Contraindications
  • Renal Impairment: Avoid Metformin in cases of severe renal impairment or dysfunction, as it relies on renal elimination for excretion. Regular monitoring of renal function is essential to ensure safe use.
  • Hepatic Insufficiency: Exercise caution in patients with hepatic insufficiency, and closely monitor liver function when using Metformin. Consultation with healthcare providers is advised to assess safety.
  • Heart Failure: Individuals with heart failure should use Metformin cautiously, as its use may exacerbate this condition. Regular cardiac assessments and medical supervision are recommended for those with heart failure considering Metformin.
  • Lactic Acidosis Predisposition: Metformin should be avoided in conditions that may predispose individuals to lactic acidosis, such as acute or chronic metabolic acidosis. Healthcare providers should carefully evaluate the risk factors before prescribing Metformin.

Drug Interactions

Metformin may interact with medications that affect renal function or involve the use of iodinated contrast agents, potentially increasing the risk of lactic acidosis. Certain drugs, like cimetidine, can alter Metformin absorption, emphasizing the importance of close monitoring and dosage adjustments when co-administered. Healthcare professionals should consider potential interactions and adjust treatment plans accordingly to ensure the safe and effective use of Metformin.

Potential Side Effects

Common side effects of Metformin include gastrointestinal symptoms such as nausea, diarrhea, and abdominal discomfort, especially when initiating treatment. These effects are often transient and can be mitigated by taking Metformin with meals or as directed by a healthcare professional. Persistent or severe side effects should be promptly reported to a healthcare provider for further evaluation and potential dosage adjustments.

Contraindications
  • Renal Impairment: Avoid Metformin in cases of severe renal impairment or dysfunction, as it relies on renal elimination for excretion. Regular monitoring of renal function is essential to ensure safe use.
  • Hepatic Insufficiency: Exercise caution in patients with hepatic insufficiency, and closely monitor liver function when using Metformin. Consultation with healthcare providers is advised to assess safety.
  • Heart Failure: Individuals with heart failure should use Metformin cautiously, as its use may exacerbate this condition. Regular cardiac assessments and medical supervision are recommended for those with heart failure considering Metformin.
  • Lactic Acidosis Predisposition: Metformin should be avoided in conditions that may predispose individuals to lactic acidosis, such as acute or chronic metabolic acidosis. Healthcare providers should carefully evaluate the risk factors before prescribing Metformin.

Drug Interactions

Metformin may interact with medications that affect renal function or involve the use of iodinated contrast agents, potentially increasing the risk of lactic acidosis. Certain drugs, like cimetidine, can alter Metformin absorption, emphasizing the importance of close monitoring and dosage adjustments when co-administered. Healthcare professionals should consider potential interactions and adjust treatment plans accordingly to ensure the safe and effective use of Metformin.

For Superpower Members, text your private concierge at any time with any question

Our Curation Standards

At Superpower, we believe in scientific rigor and transparency. We have a dedicated medical and research team that follows a multi-faceted curation and evaluation process to select only the most trusted and efficacious products and protocols for our members.

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